Opioids

Kratom is an herb derived from a leafy Southeast Asian tree and contains two psychoactive compounds that can bind to opioid receptors in the brain and produce a pharmacological response similar to effects produced by other opioid agonists, such as morphine. As of April 2025, 24 states and the District of Columbia regulate kratom. This document: (1) provides a singular resource for each jurisdiction’s laws; (2) allows for a comparison of these laws between jurisdictions; and (3) identifies and highlights interesting provisions. ...

Syringe services programs (SSP) are harm reduction programs that provide a wide range of services including, but not typically limited to, the provision of new, unused hypodermic needles and syringes and other injection drug use supplies, such as cookers, tourniquets, alcohol wipes, and sharps waste disposal containers, to people who inject drugs. In this summary, readers will find information with respect to SSPs for each state, including citations to applicable statutes and/or regulations, whether the state allows SSPs by statute, whether there are any municipal or county ordinances or regulations in place within the state, program components, miscellaneous provisions, and information on any pending legislation....

In an effort to save lives, states have implemented laws to make it easier for first responders and the general public to obtain overdose reversal agents, such as naloxone. Additionally, to encourage people to assist an individual who is or may be suffering an overdose, the majority of states also enacted laws which protect laypeople who administer overdose reversal agents, in good faith, in an emergency from civil and/or criminal liability. The Legislative Analysis and Public Policy Association (LAPPA) undertook an extensive research project to determine the current status of overdose reversal agent access laws throughout the United States, including the District of Columbia and all U.S. territories. As of January 2025, all 50 states and the District of Columbia have some form of an overdose reversal agent access law....

The Heller School for Social Policy and Management at Brandeis University and the Legislative Analysis and Public Policy Association, together published a report that includes a comprehensive review of the laws and regulations that apply to methadone for opioid use disorder (OUD) to determine which laws and regulations would need to be amended in order to support pharmacy-based methadone treatment for OUD. This analysis (1) includes a discussion of the agencies involved in governing methadone for OUD treatment; (2) explains the provision in federal Controlled Substances Act that creates the regulatory scheme for methadone treatment; (3) describes DEA regulations governing Narcotic Treatment Programs; and (4) summarizes the general types of state laws and regulations that place additional restrictions on methadone for OUD treatment....

In this fact sheet the Legislative Analysis and Public Policy Association (LAPPA) discusses the emergence of  "tusi," which is also known as pink cocaine. Tusi is a group of psychedelic drugs common amongst clubgoers, dyed pink, that actually rarely contains cocaine. While tusi itself is not controlled under the Controlled Substances Act, its individual components like ketamine and fentanyl often are, and because users rarely know what is in the particular mix they are ingesting, they cannot anticipate the side effects....

The Legislative Analysis and Public Policy Association (LAPPA), in partnership with the Institute for Intergovernmental Relations, developed several resources related to overdose fatality review (OFR), including a complete summary of state OFR laws, a guide on how OFR teams can obtain information from the Indian Health Service, and a guide on how OFR teams can obtain information from the Veterans Health Administration....

In this fact sheet the Legislative Analysis and Public Policy Association (LAPPA) details the changes to the "primary diagnosis other than OUD" regulation. The fact sheet also covers the federal regulatory scheme for methadone for OUD and explains what led SAMHSA to revise its regulations. ...

In this document, the Legislative Analysis and Public Policy Association (LAPPA) examines state-level statutes and regulations related to substance use during pregnancy and whether such use during pregnancy is considered child abuse or neglect in the jurisdiction. ...